Sprite Comic's guide lines.

Okay when you post sprite comics, do not post something that's 18+ or immediate ban. If the characters in there cuss, then try to keep flamming at a minimum or censor it. That's all---peace

Guide to Making a Great Comic/Sprite Comic---Taken from VG CATS
VG Cats Presents their FAQ:

Q: I want to make a comic, what do I do?
A: Well you can start by asking yourself a few questions. What kind of comic do you want to create? What interests you? The best of comics are usually a very personal thing. Find something that works for you and go with it.

A few pitfalls to watch out for...
Best avoid sprites unless it's really, REALLY funny. Also inside jokes never work. It is personal but if no one gets it but you and those invloved, then no one is gonna stick around to read it.

As for hosting it you can do so for free over at Drunk Duck, Smack Jeeves, or pay to have it hosted. If you choose to spend some cash just give a look on Google.